I was diagnosed with major depressive disorder 8 years ago. I have been on lots of medications. and found?

that Cymbalta is the only one that helps , but only to a point. I had a bad experience with Pristiq and ended up in the ER. I know I have what is known as drug resistant depression. I stay in the bed a lot and don't want to be around anyone. I have been in counseling for along time, but the depression overwhelms me so matter how much I try to do. I'm busy when I'm awake, so I have plenty to do. I just feel so defeated all the time. What else is a person to do when they do all they can?